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  • Homer Simpson, the father, who is overweight, lazy and works at a nuclear power plant.
  • Marge Simpson, the mother, a housewife, who is very tolerant (understanding) of her family.
  • Bart Simpson, the 10-year old son, who gets in trouble.
  • Lisa Simpson, the 8-year old daughter, who is very smart.
  • Maggie Simpson, the baby girl, who can not talk. She talks once and never speaks again. She is always doing mischief.
  • Abraham Simpson, the father of Homer Simpson. He lives in an old folk's home.
  • Patty and Selma Bouvier, Marge's sisters, whom have rough voices and often smoke cigarettes. Note that in one episode, Patty is revealed to be a lesbian. Selma has been married several times.
  • Mona Simpson, the mother of Homer Simpson; wife of Abe Simpson.
  • Santa's Little Helper, the family dog, a former racing greyhound.
  • Snowballs (I-V) and Coltrane, pet cats. All have died at one point in the series. The current cat is Snowball V (though she is called Snowball II)

Some of the many different characters who appeared on the show include:

  • Montgomery Burns, Homer's greedy, evil boss
  • Waylon Smithers, Montgomery Burns' assistant
  • Moe Szyslak, a grumpy bartender who works at a bar
  • Barney Gumble, one of Homer's friends, a gifted alcoholic
  • Kent Brockman, a television news journalist
  • Mayor Quimby, the corrupt mayor of Springfield
  • Lenny Leonard and Carl Carlson, two of Homer's coworkers.
  • Krusty The Clown, TV star and host of a popular Children's/Comedy/Variety show who smokes and drinks a lot
  • Doctor Hibbert, the Simpsons' family doctor
  • Ned Flanders, the Simpsons' religious devout neighbour
    • Ned has two shy children, Rod and Todd. His wife Maude died at an auto race.
  • Milhouse Van Houten, Bart's nerdy best friend
    • His parents, Kirk and Luann.
  • Nelson Muntz, school bully
  • Comic Book Guy, comic book store owner
  • Apu Nahasapeemapetilon, convenience store owner
    • Apu and his wife Manjula have eight infant children.
  • Seymour Skinner, principal of the school
  • Chief Wiggum, chief of police who is not good at his job
    • Chief Wiggum's son, Ralph, is a classmate of Lisa.
  • Jasper, friend of Grandpa's
  • Captain McAllister, sea captain
  • Otto Mann, who drives the school bus
  • Bumblebee Man, Spanish-speaking TV actor
  • Itchy and Scratchy, cartoon cat and mouse who are a different more violent version of Tom and Jerry
  • Troy McClure, out of work actor. He was once married to Selma.
  • Snake(Jailbird), robber and criminal.
  • Old Gil Gunderson, a salesman who has bad luck.
  • Sideshow Bob (Robert Terwilliger), was Krusty the Clown's assistant before he was jailed after framing Krusty.
    • He was married to Selma once, has tried to kill Bart several times, and has gone to prison.
  • Fat Tony, the town's chief gangster who has a group of mobsters, including Legs and Louie, and occasionally Icepick and Johnny Tightlips.
  • Sideshow Cecil (Cecil Terwilliger), Sideshow Bob's somewhat evil brother, whom was also once a clown
  • Janey, Lisa's best friend
  • Ranier Wolfcastle, The Arnold Schwarzenegger-like Hollywood action hero of Springfield who is in a lot of movies in Springfield
  • Mr Largo, the Springfield Elementary music teacher
  • Bruno, the stereotypical Australian boy telephoned by Bart in the "Simpson's in Australia" episode
  • Superintendent Chalmers, The superintendent of all Springfield elementary schools who does not like Principal Skinner
  • Agnes Skinner, The mean mother of Principal Skinner
  • Mrs. Krabappel and Ms. Hoover, Bart and Lisa's teachers, who both do not want to live or teach because of they do not have relationships
  • Groundskeeper Willie, janitor at Springfield Elementary School.
  • Cletus, the hillbilly of Springfield, has a wife named Brandine and have about 30 children.
  • Hans Moleman, a man who drinks and says he's only 31 years old, while he looks old.
  • Sideshow Mel, Krusty's second assistant who replaced Bob after going to prison for trying to frame Krusty for murder. He does not say much on the Krusty show (talks with a whistle) and once tried to get gum out of his hair with a bone ....it just made matters worse.

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